ALOX15 and asthma: However, the inhibition of various proinflammatory mediators such as IL-4, IL-13, TGF-β1, 15-LOX, and reduction of 15-LOX metabolites such as 13-(S)-HODE and 9-(S)-HODE, are likely to lead to reduction of bronchial epithelial injury and consequent airway remodeling could be possible mechanisms by which baicalein reduces asthma features.