Dysregulation of β-catenin and other Wnt components lead to nuclear localization of β-catenin, activation of Wnt target genes, including c-Myc, cyclin D1, cyclooxygenase-2, matrix metalloproteinase-7, gastrin, and ITF-2 [33]–[39] and enhance tumor formation [40]. Here, PTGS2 is linked to neoplasm.