We also examined the subcellular localization of HIGD1A during pathological states in vivo, including in human neonatal brains following HIE and infarcted mouse hearts, as well as human tumor xenografts and glioblastoma biopsies from patients before and after treatment with the antiangiogenesis agent Bevacizumab/Avastin. This evidence concerns the gene HIGD1A and neoplasm.