The multivariate logistic regression analysis revealed that diabetes (OR  = 4.405, 95% CI [1.573 – 12.334], P = 0.005) significantly increased the positivity rate of the serum anti-PF4/heparin antibody in the MHD patients, and the number of weekly dialyses (≥3 times) reduced the positivity rate of the serum anti-PF4/heparin antibody (OR  = 0.324, 95% CI [0.114 – 0.925], P = 0.035). Here, PF4 is linked to diabetes mellitus.