The structure of LRRK2 suggests that it is multifunctional; it is a 286 kDa protein that contains several protein-protein interaction domains, a kinase domain, and a GTPase [3].The G2019S mutation increases LRRK2 kinase activity [4], [5], [6], [7], suggesting that therapies designed to reduce kinase activity may be relevant for treating PD [8]; however, the biological functions of LRRK2 are poorly understood. Here, LRRK2 is linked to Parkinson disease.