FH and cyst: Macroscopic analyses of kidneys from 30-week-old mice (Figure 2D) indicated that expression of either transgene was sufficient to ameliorate the increased renal mass in FH1KO mice, and microscopic analysis at three time points (13, 20, and 30 weeks) confirmed that transgenic expression of cytosolic FH was sufficient to suppress cyst development (Figures 2E–2H).