In a recent animal study, it has reported that orally administered voglibose, another AGI, protects the myocardium against ischemia–reperfusion injury through the stimulation of GLP-1 receptors, the activation of PI3K-Akt endothelial NOS pathways, and the opening of mitochondrial KATP channels in rabbits after 30 minutes of coronary occlusion and 48 hours of reperfusion [12]. This evidence concerns the gene NOS3 and ischemia.