Removal of SATB1 from aggressive breast cancer cells not only reversed metastatic phenotypes but also inhibited tumor growth, indicating its key role in breast cancer progression [9].,Barboro et al. reported that the interaction of SATB1 with specialized DNA sequences called matrix attachment regions (MARs) was important for the aggressive potential of prostate cancer cells [14]. The gene discussed is SATB1; the disease is prostate carcinoma.