In fact, several preclinical studies had demonstrated that androgens can induce proliferative changes in cancer cell lines and promote tumorigenesis in animal models by androgens receptor (AR) [19,20] Maasberg et al. [21] (1989) found that application of testosterone resulted in a 3-fold increase in cell proliferation in a cloning assay, whereas estrogen had no influence on tumor growth. Here, AR is linked to neoplasm.