Higher MMP-12 concentrations were detected in aorta specimen and serum samples of the AD group compared with aorta specimens of the CAD group and serum samples of healthy controls (3.7±0.9, 0.6±0.16 vs. no detectable quantity of MMP-12, 0.05±0.03ng/ml, P<0.05, P<0.05, respectively) (Figure 7). Here, MMP12 is linked to Alzheimer disease.