High levels of circulating CRP have recently been linked to poor prognosis in various malignancies, including oral SCC [6], esophageal SCC [7,8], non-small cell lung cancer [9], small cell lung cancer [10], melanoma [11], hepatocellular carcinoma [12,13], breast cancer [14], endometrial cancer [15], renal cell carcinoma [16,17], urothelial carcinoma [18], castration-resistant prostate cancer [19], and even diffuse large B cell lymphoma [20]. The gene discussed is CRP; the disease is esophageal squamous cell carcinoma.