Obstetric and perinatal problems reminiscent of those seen in other connective tissue disorders have also been present in several individuals with BCS: premature birth after premature rupture of membranes (V: 1, BCS-002), and primary primiparous cervical incompetence, resulting in second trimester pregnancy loss (IV:4, BCS-001) have each been observed in individuals with mutations in PRDM5[3]. This evidence concerns the gene PRDM5 and cervical incompetence.