Down-regulation of pathways controlling cell proliferation such as pathways 4-Cell cycle:G2/M DNA damage checkpoint regulation, 8 -Mitotic roles of PLK, 13 -Cyclins and cell cycle regulation, 23 -Molecular mechanisms of cancer and 25 -Cell cycle: G1/S checkpoint regulation was also observed (Figure 3, green bars). This evidence concerns the gene PLK1 and cancer.