CDKN1A and melanoma: Such a response was anyway weaker in these latter cells and pathway trends markedly differed between melanoma and fibroblasts (i.e., p21/CDKN1A, FC = 19.35 in melanoma cells versus FC = 4.29 in fibroblasts, or CCNB1, FC = 0.43 and CDC25B, FC = 0.47 in melanoma cells with no modulation in fibroblasts; Table 4).