EP300 and breast cancer: To this regard, a recent report by Sen and colleagues [53] demonstrated that curcumin reverses doxorubicin resistance in breast cancer by inhibiting NF-κB activation and thus rescuing p300 coactivator, which in turn becomes available to the p53 transcription factor, and finally allows p53-dependent transactivation of proapoptotic proteins such as Bax, PUMA and Noxa.