ATM and breast cancer: Additional pathways such as 4 -Cell cycle:G2/M DNA damage checkpoint regulation, 5 -p53 signalling, 10 -Hereditary breast cancer signalling, 11 -ATM signalling, 26 -Role of BRCA1 in DNA damage response, and 27 -Role of CHK proteins in cell cycle checkpoint control are all related to DNA repair mechanisms and cell death triggering (Table 3 and Additional files 3, 4, 5, 6, 7, 8), evidencing a DNA damage as cell response to D6 treatment.