Our study i) shows a selective astrocytic upregulation of B1R, being almost exclusively associated with Aβ plaques, in the hippocampus of APP mice with impaired memory, and ii) demonstrates that chronic blockade of B1R significantly improves learning and memory performances, cerebrovascular function, as well as several anatomopathological AD hallmarks in APP mice with a fully developed pathology. Here, APP is linked to Alzheimer disease.