Knowing that neuroinflammation mediated by astrocytes and microglia is induced in AD [44], as replicated in the brain of APP mice by the enhanced GFAP (astrocytes, Figure 7A) and Iba1 (microglia, Figure 7B) immunofluorescence, we sought to investigate whether the SSR240612-induced decrease in amyloidosis would be accompanied by a reduction in activated glial cells. Here, APP is linked to Alzheimer disease.