The aim of the present study was to assess the gene expression profiles of MMP-2, MMP-9, MT1-MMP, TIMP-1, TIMP-2, RECK, VEGF-A and VEGF-164 and the protein levels of MMP-2, MMP-9 and VEGF-A in canine B and T-cell lymphomas. The gene discussed is TIMP2; the disease is T-cell non-Hodgkin lymphoma.