VEGFA and non-small cell lung carcinoma: In 2004, bevacizumab, a monoclonal antibody directed at all five isoforms of VEGF, was FDA approved to treat NSCLC and has since been approved to treat metastatic colorectal cancer, metastatic kidney cancer, and glioblastoma (GBM) in patients who had progressed after prior treatment (Cohen et al., 2007a,b, 2009).