Several primary oncogenic events including, mutational activation of the Ras (Grugel et al., 1995) and Wnt (Zhang et al., 2001) pathways, also upregulate VEGF expression and VEGF is known to be overexpressed in many types of cancer including colon cancer, non-squamous non-small cell lung cancer (NSCLC), kidney cancer, and brain cancers. The gene discussed is VEGFA; the disease is cancer.