It is well-established that the E5 gene product of HPV types 16 or 18 can inactivate p53 function leading to malignant transformation (Kim et al. 2010) and that p53 is wild type but not expressed in cervical cancers, although some cervical cancers do express mutant p53 and not infected by HPV. This evidence concerns the gene TP53 and cervical carcinoma.