In addition, p97 or its adaptors regulate proteins involved in tumorigenesis, such as Aurora B (overexpressed in cancer cells and implicated in genome stability), IκB [potential inhibitor of the pro-survival function of nuclear factor kappa B (NFκB)] or HIF1a (promoter of tumor angiogenesis and metastases; Asai et al., 2002; Ramadan et al., 2007; Alexandru et al., 2008; Dobrynin et al., 2011). The gene discussed is VCP; the disease is cancer.