GPER1 and cancer: GPER is widely expressed in cancer cell lines and primary tumors of the breast (Carmeci et al., 1997; Filardo et al., 2000; Revankar et al., 2005; Albanito et al., 2008a), endometrium (Vivacqua et al., 2006a; Leblanc et al., 2007; He et al., 2009), ovaries (Albanito et al., 2007, 2008b; Henic et al., 2009), thyroid (Vivacqua et al., 2006b), lung (Siegfried et al., 2009), prostate (Chan et al., 2010), and testicular germ cells (Franco et al., 2011).