Nevertheless, exenatide treatment upregulated PAP/Reg3b (pancreatitis-associated protein) expression as already observed in the course of pancreatic carcinogenesis and pancreatitis (Graf et al., 2006; Gigoux et al., 2008; Koehler et al., 2009; Tatarkiewicz et al., 2010). This evidence concerns the gene REG3A and pancreatitis.