Clarifying this subject is particularly important in light of antiangiogenic approaches in pancreatic cancer and it should be addressed whether anti-VEGF antiangiogenic therapy can determine a more invasive phenotype only when targeting VEGFR by receptor tyrosine kinase inhibitors or it could also be a drawback of the use monoclonal antibodies directed against VEGF. This evidence concerns the gene VEGFA and familial pancreatic carcinoma.