NFKB1 and familial pancreatic carcinoma: A complete inhibition of NF-κB activation by blocking degradation of both IκBα and IκBβ proteins is critical in order to suppress a potential NF-κB feedback reactivation induced by various anti-cancer agents, and in turn sensitize pancreatic cancer cell lines to apoptosis induced by these drugs (Dong et al., 2002).