Increased expression of the pro-apoptotic Bcl-2 family members Bax and Bid, but not Bim, was observed following Ad-eIF5A1 infection (Figure 3), suggesting that p53-mediated induction of Bcl-2 pro-apoptotic family members may contribute to eIF5A1-induced apoptosis. This evidence concerns the gene BCL2L11 and infection.