We observed that Bitox, which carries the native BoNT/A targeting domain, could cleave SNAP25 in SH-SY5Y neuroblastoma cells, which is in accord with the ability of native BoNT/A to target these cells (Darios et al. 2010; Thirunavukkarasusx et al. 2011). Here, SNAP25 is linked to neuroblastoma.