KDR and cancer: Our results are supported by the previous findings as follows: 1) EGCG suppressed tumor growth by blocking the induction of VEGF in human colon carcinoma cells [31]; 2) EGCG inhibited VEGF/VEGFR axis by suppressing the expression of HIF-1α in human colorectal cancer cells [32]; and 3) EGCG inhibited cancer progression by decreasing NFκB activation [33].