Five genomic loci corresponded to the criteria mentioned, and were further analyzed in the group of female Caucasian breast cancer patients and controls: DNMT1 SNP (A201G, rs2228612), DNMT3A SNPs (G301C, rs34843713 and G301A, rs34191084) and DNMT3B SNPs (C501T, rs406193 and G301A, rs35846833). This evidence concerns the gene DNMT3A and breast cancer.