Germline mutations of PTEN are associated with the PTEN hamartoma-tumor syndromes (PHTS), a family of hamartomatous polyposis syndromes including Cowden syndrome, Bannayan–Riley–Ruvalcaba syndrome, Proteus syndrome, and Proteus-like syndrome (Chow and Baker, 2006). The gene discussed is PTEN; the disease is PTEN hamartoma tumor syndrome.