These 12 genes are EGFR, FGFR2, FGFR3, IL8, PTPRF, TNC, CXCL13, COL11A1, CHP2, SHC4, PPP2R2C, and WNT4. Based on these interactions we propose a new signaling network for melanoma (Fig. 2). This evidence concerns the gene SHC4 and melanoma.