Second, our method identified a core signature of 12 genes (i.e., EGFR, FGFR2, FGFR3, IL8, PTPRF, TNC, CXCL13, COL11A1, SHC4, CHP2, PPP2R2C and WNT4) that are closely associated with known melanoma driver genes. The gene discussed is SHC4; the disease is melanoma.