PPP2R2C and melanoma: Second, our method identified a core signature of 12 genes (i.e., EGFR, FGFR2, FGFR3, IL8, PTPRF, TNC, CXCL13, COL11A1, SHC4, CHP2, PPP2R2C and WNT4) that are closely associated with known melanoma driver genes.