Second, our method identified a core signature of 12 genes (i.e., EGFR, FGFR2, FGFR3, IL8, PTPRF, TNC, CXCL13, COL11A1, SHC4, CHP2, PPP2R2C and WNT4) that are closely associated with known melanoma driver genes. This evidence concerns the gene PTPRF and melanoma.