Along with upregulation of these immunosuppressive genes, there was a significant early down-modulation of positive immune response regulating genes such as JUN, FOS, CD69, CD83, STAT4, GADD45A, and SIGLEC10 in PBMC from LASV exposed NHPs (as shown in Table 1), suggesting the lack of key players in the generation of immune response to infection. This evidence concerns the gene STAT4 and infection.