Blockade of CD244/2B4 receptor signaling inhibits degranulation and IFN-γ production in CD8+ T cells of patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), suggesting that CD244/2B4 might play roles in promoting inflammatory neurological disease [32]. This evidence concerns the gene CD244 and tropical spastic paraparesis.