[41], [54] However, we did not observe consistent increases in Dleu2, the miR-15a primary transcript, by qRT-PCR in s-α-miR-106a∼363 sponge expressing cells, arguing against a major role for a transcriptional mechanism. Interestingly, miR-15a expression in the mouse has recently been shown to be regulated by another microRNA, miR-709, at the level of processing, and similar mechanisms may play a role in Ewing Sarcoma. [55], [56]. The gene discussed is DLEU2; the disease is Ewing sarcoma.