CDK4 and diffuse large B-cell lymphoma: [22], [31] Furthermore, three members of the miR-17 family (miR-17, miR-106b and miR-106a) each directly inhibit p21 in Diffuse Large B-cell Lymphoma and in Burkitt’s Lymphoma to increase cellular proliferation. [23] Importantly, in this context, specific blockade of miR-106a alone also resulted in increased expression of Bim and decreased expression of CDK4/CDK6.