[24] Interestingly, the same protein has also been addressed to be associated with the treatment resistance of various cytotoxic agents in various cancers. [25], [26], [27], [28] This East Asian restricted BIM polymorphism, and other yet indentified genetic polymorphisms, might also lead to poorer treatment responses in East Asian CLL patients and result in the inferior RS in Taiwanese CLL patients found in the current study. The gene discussed is BCL2L11; the disease is B-cell chronic lymphocytic leukemia.