C1QL3 and Hyperglycemia: Recombinant CTRP13 promotes glucose uptake in cultured myotubes, hepatocytes, and adipocytes and ameliorates fatty acid-induced insulin resistance in cultured hepatocytes by suppressing lipid-induced stress signaling (i.e., JNK) [18], suggesting that increases in CTRP13 in vivo may be a compensatory response to hyperglycemia.