MAPK8 and pituitary tumor: We found no expression of JNK protein, the Wnt/polarity pathway effector, in normal pituitaries and a weak staining (less than 10% of the cells) was observed in 12.8%, 5.5%, 5.5% of ACTH-, GH-secreting and non-secreting pituitary tumors, respectively, without difference among pituitary tumors and normal pituitaries (Figure 2).