There are no differences in the expression of canonical and non-canonical Wnt pathway genes between each pituitary tumor subtype and normal pituitaries, as well as among all pituitary tumor subtypes, except for WISP2 which was over-expressed in ACTH-secreting tumors compared to normal pituitaries (4.8x; p = 0.02), to non-secreting pituitary tumors (7.7x; p = 0.004) and to GH-secreting tumors (5.0x, p = 0.05). Here, CCN5 is linked to pituitary tumor.