For example, Guo et al. reported that the rate of methylation of THBS1 was significantly higher in gastric cardia adenocarcinoma than that in the corresponding normal tissues and accompanied by reduction of its mRNA and protein expressions [22], and Guerrero et al. also reported that the hypermethylation of THBS1 is associated with a poor prognosis in penile squamous cell carcinoma [23]. This evidence concerns the gene THBS1 and gastric cardia adenocarcinoma.