DISC1 and schizophrenia: While BTBR mice are used as a model of behaviors characteristic of ASD, they have a spontaneous deletion of the Disc1 gene [61], one of the major genetic risk factors for schizophrenia [62], and the increased kynurenic acid levels and cognitive deficits found in the present study suggest that they may be relevant as a model of phenotypic deficits associated with schizophrenia.