So we investigated whether S100A8 and S100A9 can regulate Wnt/β-catenin pathway, which is closely related to the progression, metastasis and prognosis of CRC [57]-[60], and found that the recombinant S100A8 and S100A9 proteins could enhance accumulation of β-catenin, and upregulate mRNA expression of c-myc and MMP7, the target genes of the pathway, in the cell lines. The gene discussed is S100A8; the disease is colorectal carcinoma.