These findings are in agreement with previous data, showing that extracellular S100A8 and S100A9 proteins promoted cell viability and migration in various human cancer cells such as MCF-7, MDA-MB231, SHEP, Kelly, CT-26, PNT1A, HepG2, HUVEC and neutrophil [15], [18]-[21]. The gene discussed is S100A8; the disease is cancer.