Based on the previous studies showed that β-catenin upregulation was involved in the proliferation and migration of colon cancer cells [61]-[65], we then explore whether upregulation of Wnt/β-catenin pathway was responsible for S100A8- or S100A9-induced promotion of cell viability and migration, and observed that S100A8- and S100A9-induced survival and migration of CRC cells could be partially mediated by elevating β-catenin and upregulating Wnt/β-catenin pathway. The gene discussed is S100A8; the disease is colonic neoplasm.