S100A8 and malignant colon neoplasm: RAGE has been proposed to serve as a primary receptor for S100 proteins in the extracellular space, and plays an important role in S100A8- or S100A9-induced proliferation and migration of prostate and breast and colon cancer cells involving the MAPK/NF-κB signaling [18]–[20], [56], [70]–[71].