Our data showed that expression of S100A8 and S100A9 in the poorly differentiated CRC tissues was higher than that of the well and moderately differentiated CRC tissues (p<0.05 and p<0.05, respectively), and that they were frequently found in the patients with lymph nodes metastasis (p<0.01 and p<0.01, respectively). This evidence concerns the gene S100A9 and colorectal carcinoma.