The Th2 cytokines IL-4 and IL-13, which play a critical role in asthma, “alternatively” activate macrophages and induce receptors, cytokines, enzymes, and change phagocytosis, proliferation, and other cellular processes that enable AAMs to regulate their surrounding leukocytes, parenchymal cells, and environment [3]–[5]. The gene discussed is IL13; the disease is asthma.