In regular culture condition which exhibits androgenic activity [47], the endogenous Cdc25C protein level, but not Cdc25A or B, is about 20% lower in AS LNCaP C-33 cells which have a slow growth rate and low tumorigenicity, than in AI LNCaP C-81 cells which grow rapidly and are highly tumorigenic, mimicking the advanced stages of PCa (Fig. 1) [26], [28], [41]. The gene discussed is CDC25C; the disease is posterior cortical atrophy.