CDC25B and posterior cortical atrophy: While Cdc25B protein is expressed in all PCa cells examined in our experiments, our analyses on the expression profile of Cdc25 in cells cultured in both regular medium and SR condition (Fig. 1) and in the presence of androgens (Fig. 2A & 2B) show that androgens only have up-to 2-fold effect on Cdc25B protein level.