Therefore, we assessed in 1,976 German individuals at increased risk for type 2 diabetes whether common single nucleotide polymorphisms (SNPs; with minor allele frequencies [MAFs] ≥0.05) in the human FNDC5 locus contribute to the prediabetic phenotypes overweight, glucose intolerance, insulin resistance, or impaired insulin release. Here, FNDC5 is linked to Insulin resistance.