In NMO/NMOSD, correlations among proinflammatory cytokines/chemokines, (CXCL8, GM-CSF, G-CSF, IL-6, IFN-γ and CXCL10) were prominent in the relapse phase, while in RRMS, correlations among Th2 and potential anti-inflammatory cytokines/chemokines, (IL-1ra, CCL4, CCL11, IL-9, and IL-15) were observed in the relapse and/or remission phases. This evidence concerns the gene IL6 and neuromyelitis optica.