Rho correlation coefficients of cytokines/chemokines between RRMS and NMO/NMOSD in the relapse phase were significantly different in three combinations (IL-6 and GM-CSF: corrp = 0.034; G-CSF and GM-CSF: corrp = 0.034; GM-CSF and IFN-γ: corrp = 0.034). The gene discussed is CSF2; the disease is neuromyelitis optica.