NOTCH3 and acute lymphoblastic leukemia: Specifically, methylation frequencies of these genes in B-ALL vs. T-ALL were 100 vs. 50% for Notch3 (P<0.05), 86% vs. 50% for Hes5 (P<0.05), 86% vs. 50% for Hes2(P<0.05), 57% vs. 25% for Hes4 ((P<0.05, Figure 1A&B).