BACE1 and parasitic infectious disease: Regarding the C3H/He mice, which display remarkable susceptibility to T. cruzi, infection groups that received at least a single immunization with recombinant adenovirus-ASP2 were able to reduce the peak of parasitemia (Figure 4C, p<0.001), control tissue pathology (Figure S2) and prolong survival compared to the groups immunized with control recombinant viruses (Figure 4D p<0.0005).