PLOD1 and cerebrovascular disorder: In the regression including continuous variables of metabolic parameters as covariates (see Table 3), the significant correlations of FT and FE2 with cerebrovascular disease disappeared, and instead, elevated T/E2 ratio, LH and C-peptide were correlated with increased incidence of cerebrovascular disease (P<0.05), with an exp(B) value of >1000, 1.1 and 4.09, respectively.