In this study, we found that decreased VEGF and VEGFR protein levels may be attributable to tumor angiogenesis inhibition in rabbits with VX2 cancer after arterial heated lipiodol infusion, but the clinical benefits of this approach need further evaluation, such as lipiodol viscosity change and biodistribution altering with increased temperature and so on, should be considered. This evidence concerns the gene KDR and neoplasm.