While NKX3-1 was also expressed in Hodgkin lymphoma (HL), multiple myeloma (MM), B-cell lymphoma (BCL) and additional DLBCL cell lines, NKX2-1 was nearly undetectable in the same set of 25 lymphoma cell lines (Fig. 1A), prompting analysis of NKX2-1 and NKX3-1 in primary cells, including thyroid, lung and particular hematopoietic samples to chart physiological tissue specificity in the blood system. This evidence concerns the gene NKX2-1 and diffuse large B-cell lymphoma.