Genetic studies have shown that the risk of AMD is related to polymorphisms of a number of immune related genes, including complement factor H (CFH)[7]–[10], complement component 2 and factor B (C2/CFB)[11], complement component 3 (C3)[12]–[14], Toll-like receptor (TLRs)[15], and fractalkine receptor (CX3CR1) genes[16]–[19], although a recent study by Zerbib et al did not confirm the association between CX3CR1 polymorphism (T280M) and neovascular AMD in a French population [20]. The gene discussed is C3; the disease is age-related macular degeneration.