The most robust association has been observed for a two-marker haplotype (HEP3) spanning a 62 kbp genomic region from intron 1 to exon 2 of the DISC1 gene, which was originally found to confer significant risk of schizophrenia only to male probands in a sample of Finnish families [68], and has subsequently been associated to the neurocognitive measure of visual working memory only in males [69]. Here, DISC1 is linked to schizophrenia.