Importantly, the NDE1/LIS1/NDEL1 complex is part of the disrupted in schizophrenia-1 (DISC1) pathway, one of the most relevant pathways underlying psychosis, and directly binds the DISC1 gene; furthermore, NDE1 subcellular localization and protein-protein interactions are modulated through phosphorylation by the cAMP-activated protein kinase A (PKA), and DISC1 is able to modulate the PKA phosphorilation of NDE1 via regulation of the activity of PDE4, a cAMP-hydrolyzing enzyme which creates a co-complex with DISC1 and NDE1/LIS1/NDEL1 [66], [67]. The gene discussed is PDE4A; the disease is schizophrenia.