We observed an association with a tagging SNP on MBL2 (rs1982266; OR = 0.36, 95% CI = 0.19–0.66 for homozygous recessive compared to homozygous dominant, test for trend p = 0.003) and glioma risk in our preliminary analysis of SNPs selected from HapMap that cover 10 genes in the complement pathway. Here, MBL2 is linked to central nervous system cancer.