Despite the limited observational data on the relationship between BCL-2-gene family polymorphisms and endometrial cancer, our findings on the associations between genetic variants in the BCL2 gene and endometrial cancer risk are consistent with findings from previous human tumor tissue studies, which have clearly demonstrated a role for members of the BCL-2 family of genes, particularly the BCL2 and BAX genes, in endometrial carcinoma [11], [12], [14]–[16]. This evidence concerns the gene BCL2 and endometrial cancer.