We have generated a new cell penetrating peptide that specifically binds to PP2Ac (DPT-C9h or DPT-C9), targets caspase-9/PP2Ac interaction, leading to caspase-9 activation, mitochondrial membrane permeabilization, cytochrome c release and apoptosis in a variety of human and mouse cancer cell lines. Here, CASP9 is linked to cancer.