FMO5 and endothelial dysfunction: We and others have previously shown that both phagocytic and vascular NADPH oxidases are important in inflammatory processes such as extravasation and transmigration of inflammatory cells and activation of endothelial cells, including increases in cell adhesion molecule expression and endothelial dysfunction, which are important sources for the initiation and progression of reperfusion injury and artery diseases such as atherosclerosis [2],[48],[55],[56].